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- Title
Targeting ferroptosis by natural products in pathophysiological conditions.
- Authors
Zheng, Daheng; Jin, Shikai; Liu, Pu-Ste; Ye, Jianping; Xie, Xin
- Abstract
Ferroptosis is a form of cell death that is induced by iron-mediated accumulation of lipid peroxidation. The involvement of ferroptosis in different pathophysiological conditions has offered new perspectives on potential therapeutic interventions. Natural products, which are widely recognized for their significance in drug discovery and repurposing, have shown great promise in regulating ferroptosis by targeting various ferroptosis players. In this review, we discuss the regulatory mechanisms of ferroptosis and its implications in different pathological conditions. We dissect the interactions between natural products and ferroptosis in cancer, ischemia/reperfusion, neurodegenerative diseases, acute kidney injury, liver injury, and cardiomyopathy, with an emphasis on the relevance of ferroptosis players to disease targetability.
- Publication
Archives of Toxicology, 2024, Vol 98, Issue 10, p3191
- ISSN
0340-5761
- Publication type
Article
- DOI
10.1007/s00204-024-03812-4