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- Title
Identification of SNPs and Candidate Genes Associated with Monocyte/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio in Duroc × Erhualian F 2 Population.
- Authors
Qiao, Jiakun; Xu, Minghang; Xu, Fangjun; Che, Zhaoxuan; Han, Pingping; Dai, Xiangyu; Miao, Na; Zhu, Mengjin
- Abstract
Understanding the pig immune function is crucial for disease-resistant breeding and potentially for human health research due to shared immune system features. Immune cell ratios, like monocyte/lymphocyte ratio (MLR) and neutrophil/lymphocyte ratio (NLR), offer a more comprehensive view of immune status compared to individual cell counts. However, research on pig immune cell ratios remains limited. This study investigated MLR and NLR in a Duroc × Erhualian F2 resource population. Heritability analysis revealed high values (0.649 and 0.688 for MLR and NLR, respectively), suggesting a strong genetic component. Furthermore, we employed an ensemble-like GWAS (E-GWAS) strategy and functional annotation analysis to identify 11 MLR-associated and 6 NLR-associated candidate genes. These genes were significantly enriched in immune-related biological processes. These findings provide novel genetic markers and candidate genes associated with porcine immunity, thereby providing valuable insights for addressing biosecurity and animal welfare concerns in the pig industry.
- Subjects
NEUTROPHIL lymphocyte ratio; GENOME-wide association studies; GENETIC markers; IMMUNITY; FUNCTIONAL analysis
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 17, p9745
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25179745