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- Title
A randomized trial testing digital medicine support models for mild-to-moderate alcohol use disorder.
- Authors
Quanbeck, Andrew; Chih, Ming-Yuan; Park, Linda; Li, Xiang; Xie, Qiang; Pulvermacher, Alice; Voelker, Samantha; Lundwall, Rachel; Eby, Katherine; Barrett, Bruce; Brown, Randall
- Abstract
This paper reports the results of a hybrid effectiveness-implementation randomized trial that systematically varied levels of human oversight required to support the implementation of a digital medicine intervention for persons with mild-to-moderate alcohol use disorder (AUD). Participants were randomly assigned to three groups representing possible digital health support models within a health system: self-monitored use (SM; n = 185), peer-supported use (PS; n = 186), or a clinically integrated model CI; (n = 187). Across all three groups, the percentage of self-reported heavy drinking days dropped from 38.4% at baseline (95% CI [35.8%, 41%]) to 22.5% (19.5%, 25.5%) at 12 months. The clinically integrated group showed significant improvements in mental health and quality of life compared to the self-monitoring group (p = 0.011). However, higher attrition rates in the clinically integrated group warrant consideration in interpreting this result. Results suggest that making a self-guided digital intervention available to patients may be a viable option for health systems looking to promote alcohol risk reduction. This study was prospectively registered at clinicaltrials.gov on 7/03/2019 (NCT04011644).
- Subjects
ALCOHOLISM treatment; SUPPORT groups; SELF-evaluation; RESEARCH funding; MENTAL health; MEDICAL care; DIGITAL health; STATISTICAL sampling; INTERNET; TREATMENT effectiveness; RANDOMIZED controlled trials; ODDS ratio; QUALITY of life; COMPARATIVE studies; CONFIDENCE intervals
- Publication
NPJ Digital Medicine, 2024, Vol 7, Issue 1, p1
- ISSN
2398-6352
- Publication type
Article
- DOI
10.1038/s41746-024-01241-2