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- Title
Characterization of the vaginal microbiota in Italian women with endometriosis: preliminary study.
- Authors
Sessa, Rosa; Filardo, Simone; Viscardi, Maria Federica; Brandolino, Gabriella; Muzii, Ludovico; Di Pietro, Marisa; Porpora, Maria Grazia
- Abstract
Purpose: This cross-sectional study aims to assess the interplay between the vaginal microbiota and endometriosis. Methods: 123 consecutive Italian fertile women, aged between 20 and 40 years old, were enrolled during a routine gynecological consultation; 24 were diagnosed with endometriosis and 99 did not complain of any gynecological disease. All women underwent a vaginal swab for the evaluation of the composition and diversity of vaginal microbiota by means of 16 s rDNA metagenomic sequencing. Results: Compared to women with no gynecological disease, the vaginal microbiota in women with endometriosis showed a similar abundance of Lactobacillus spp.; however, a statistically significant lower abundance in the genera Pseudomonas (p < 0.01), Bifidobacterium (p < 0.05), Novispirillum (p < 0.0000001) and Sphingomonas (p < 0.0000001), and a statistically significant increase in the abundance of the genera Escherichia (p < 0.00001), Megasphaera (p < 0.00001), and Sneathia (p < 0.0001) were observed. Conclusions: There is a complex interplay between vaginal microbiota composition and endometriosis, showing a distinct microbial signature in the bacterial genera usually found in dysbiosis.
- Subjects
FEMALE reproductive organ diseases; ITALIANS; ENDOMETRIOSIS; HUMAN microbiota; METAGENOMICS
- Publication
Archives of Gynecology & Obstetrics, 2024, Vol 310, Issue 4, p2141
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-024-07631-x