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- Title
Prevalence of human papillomaviruses in self-collected samples among women attending antenatal care in Ethiopia: a cross-sectional study.
- Authors
Runge, Isabel; Klein, Johanna M. A.; Pannen, Ann-Katrin; Abera, Semaw; Wakuma, Tariku; Gebrehiwot, Yirgu; Unverzagt, Susanne; Wienke, Andreas; Thomssen, Christoph; Kaufmann, Andreas M.; Jemal, Ahmedin; Abebe, Tamrat; Holzinger, Dana; Waterboer, Tim; Höfler, Daniela; Addissie, Adamu; Kantelhardt, Eva Johanna
- Abstract
Cervical cancer is the second most commonly diagnosed cancer in women in Ethiopia. However, data are limited on the prevalence of human papillomavirus (HPV) genotypes. Self-sampled vaginal lavages were obtained consecutively from 783 women attending 7 health facilities across Ethiopia. Genotype prevalence was assessed by Multiplex- Papillomavirus-Genotyping which detects and individually identifies 51 genotypes and 3 subtypes. Genotype-specific prevalence was described and associations with known risk factors were analysed. The overall HPV prevalence (age range 18-45) was 33.1% (95% confidence interval (CI) 29.8-36.4). The prevalence of HPV was different in the rural and urban population with 17.6% (95%CI 11.6-23.7) and 36.8% (95%CI 33.1-40.6) (p < 0.001 chi-square test), respectively. The most common high-risk types were HPV 16 (6.6%), followed by HPV 52 (4.3%), 51 and 39 (both 2.9%). Urban women compared to rural women had a higher risk of being HPV positive (odds ratio 2.36 (95% CI 1.47-3.79; p < 0.001). Age at sexual debut ≤15 years and polygamous husband (in urban women) also increased the risk of being HPV positive nearly two-fold. The high prevalence of hr-HPV in Ethiopian women in the reproductive age group shows the need for screening programs. The nonavalent HPV vaccine covers the most prevalent hr-HPV genotypes as found in this study and can therefore be used effectively. Since antenatal care is the bestutilised health service, implementing self-sampled vaginal lavage could be an opportunity for screening in this age group. Screening algorithms and triage still need to be defined to avoid over-treatment in these women.
- Subjects
HUMAN papillomavirus; CITY dwellers; RURAL women; HEALTH facilities; ETHIOPIANS; GENITAL warts
- Publication
Ecancermedicalscience, 2024, Vol 18, Issue 1676-1753, p1
- ISSN
1754-6605
- Publication type
Article
- DOI
10.3332/ecancer.2024.1739