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- Title
Oxidative Stress in Transthyretin-Mediated Amyloidosis: An Exploratory Study.
- Authors
Fiore, Marco; Cambieri, Chiara; Libonati, Laura; Moret, Federica; D'Andrea, Edoardo; Di Certo, Maria Grazia; Passananti, Claudio; Gabanella, Francesca; Corbi, Nicoletta; Garibaldi, Matteo; Chimenti, Cristina; Alfarano, Maria; Ferraguti, Giampiero; Francati, Silvia; Inghilleri, Maurizio; Ceccanti, Marco
- Abstract
Transthyretin-mediated amyloidosis (ATTR) is a systemic disease with protein precipitation in many tissues, mainly the peripheral nerve and heart. Both genetic (ATTRv, "v" for variant) and wild-type (ATTRwt) forms are known. Beyond the steric encumbrance, precipitated transthyretin seems to have a toxic effect. In this study carried out in men, we recruited 15 ATTRv patients, 7 ATTRv asymptomatic carriers, 14 ATTRwt patients and 10 young and 13 old healthy controls to evaluate the oxidative stress using FORD (Free Oxygen Radicals Defense) and FORT (Free Oxygen Radicals Test) analyses. ATTRv patients showed reduced FORD compared to ATTRwt and ATTRv asymptomatic carriers. FORD independently predicted the disease stage, with the early stages characterized by the highest consumption. These findings suggest a role for oxidative stress in the early stages of ATTRv.
- Subjects
OXIDATIVE stress; FREE radicals; PERIPHERAL nervous system; TRANSTHYRETIN; AMYLOIDOSIS
- Publication
Antioxidants, 2024, Vol 13, Issue 8, p998
- ISSN
2076-3921
- Publication type
Article
- DOI
10.3390/antiox13080998