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- Title
Association of Maternal Air Pollution Exposure and Infant Lung Function Is Modified by Genetic Propensity to Oxidative Stress.
- Authors
Vilcins, Dwan; Lee, Wen Ray; Pham, Cindy; Tanner, Sam; Knibbs, Luke D.; Burgner, David; Blake, Tamara L.; Mansell, Toby; Ponsonby, Anne-Louise; Sly, Peter D.
- Abstract
Background and objective: The association between air pollution and poor respiratory health outcomes is well established. Children are particularly at risk from air pollution, especially during the prenatal period as their organs and systems are still undergoing crucial development. This study investigated maternal exposure to air pollution during pregnancy and oxidative stress (OS), inflammation, and infant lung function at 4 weeks of age. Methods: Data from the Barwon Infant Study were available for 314 infants. The exposure to NO2 and PM2.5 were estimated. Infant lung function (4 weeks) was measured by multiple-breath washout. Glycoprotein acetyls (GlycA) (36 weeks prenatal), cord blood, and OS biomarkers were measured in maternal urine (28 weeks). A genetic pathway score for OS (gPFSox) was calculated. Linear regression was used and potential modification by the OS genotype was tested. Results: There was no relationship between maternal exposure to air pollution and infant lung function, or with GlycA or OS during pregnancy. We found an association in children with a genetic propensity to OS between NO2 and a lower functional residual capacity (FRC) (β = −5.3 mls, 95% CI (−9.3, −1.3), p = 0.01) and lung clearance index (LCI) score (β = 0.46 turnovers, (95% CI 0.10, 0.82), p = 0.01). Conclusion: High prenatal exposure to ambient NO2 is associated with a lower FRC and a higher LCI score in infants with a genetic propensity to oxidative stress. There was no relationship between maternal exposure to air pollution with maternal and cord blood inflammation or OS biomarkers.
- Subjects
LUNG physiology; AIR pollution; PULMONARY function tests; MATERNAL exposure; PRENATAL exposure delayed effects; NITRIC oxide; SMOKING; OXIDATIVE stress; ACUTE phase proteins; DESCRIPTIVE statistics; LUNG diseases; DATA analysis software; CONFIDENCE intervals; INFLAMMATION; C-reactive protein; BIOMARKERS; REGRESSION analysis; SOCIAL classes; DISEASE risk factors; CHILDREN; PREGNANCY
- Publication
Children, 2024, Vol 11, Issue 8, p937
- ISSN
2227-9067
- Publication type
Article
- DOI
10.3390/children11080937