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- Title
Microwave-assisted extraction and pharmacological evaluation of polysaccharides from Posidonia oceanica.
- Authors
Ben Salem, Yosra; Abdelhamid, Amal; Mkadmini Hammi, Khaoula; Le Cerf, Didier; Bouraoui, Abderrahman; Majdoub, Hatem
- Abstract
Microwave-assisted extraction was employed for the isolation of polysaccharides fromPosidonia oceanica(PPO). The extracting parameters were optimized adopting response surface methodology. The highest polysaccharide yield (2.55 ± 0.09%), which is in concordance with the predicted value (2.76%), was obtained under the following conditions: extraction time 60 s, liquid–solid ratio of 50:1 (mL/g) and power of 800 W. This polysaccharide, with molecular weight of 524 KDa, characterized by gas chromatography–mass spectrometry showed that PPO was mainly composed of galactose, glucose, and arabinose with molar percentages 25.38, 24.37, and 21.64%, respectively. The pharmacological evaluation of PPO using animal models at the dose of 100 mg/kg indicated a significant anti-inflammatory activity with a percentage of inhibition of edema of 54.65% and a significant antinociceptive activity with 78.91% inhibition of writhing for peripheral analgesic activity and an increase in the hot plate reaction time for central analgesic activity. Microwave-assisted extraction and pharmacological activities of polysaccharides fromPosidonia oceanica
- Subjects
POSIDONIA oceanica; POLYSACCHARIDES; INDUSTRIAL applications of microwaves
- Publication
Bioscience, Biotechnology & Biochemistry, 2017, Vol 81, Issue 10, p1917
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1080/09168451.2017.1361808