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- Title
Retrospective evaluation of COX-2 expression, histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy.
- Authors
Carvalho, S.; Stoll, A. L.; Priestnall, S. L.; Suarez‐Bonnet, A.; Rassnick, K.; Lynch, S.; Schoepper, I.; Romanelli, G.; Buracco, P.; Atherton, M.; de Merlo, E. M.; Lara‐Garcia, A.
- Abstract
Limited veterinary literature is available regarding prognostic markers for canine renal cell carcinoma ( CRCC). We retrospectively evaluated COX-2 expression, histological and clinical features associated with prognosis of CRCC. Sixty-four cases post-nephrectomy were included, 54 had histopathological assessment and 30 had COX-2 immunostaining performed. Eight dogs (13%) had metastatic disease at initial diagnosis. Twenty-seven dogs (42%) received adjuvant therapy after nephrectomy. On univariate analysis, COX-2 expression, mitotic index ( MI), histologic type, vascular invasion, neoplastic invasiveness and metastasis at diagnosis were significantly associated with overall median survival time ( MST). COX-2 score ( COX-2 score > 3 MST 420 days versus 1176 days if COX-2 score <3; P = 0.011) and MI ( MI > 30 MST 120 days versus 540 days for MI < 30; P = 0.003) were the only variables associated with CRCC outcome on multivariate analysis. The addition of MI and COX-2 immunostaining to standard histopathological evaluation would help predicting outcome in CRCC patients.
- Subjects
RENAL cell carcinoma; CANCER chemotherapy; CELL cycle; CYCLOOXYGENASE 2; CANCER in dogs; NEPHRECTOMY
- Publication
Veterinary & Comparative Oncology, 2017, Vol 15, Issue 4, p1280
- ISSN
1476-5810
- Publication type
Article
- DOI
10.1111/vco.12264