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- Title
The Use of Prebiotic and Probiotic Interventions for Treating Gastrointestinal and Psychosocial Health Symptoms in Cancer Patients and Survivors: A Systematic Review.
- Authors
Deleemans, Julie M.; Gajtani, Zen; Baydoun, Mohamad; Reimer, Raylene A.; Piedalue, Katherine-Ann; Carlson, Linda E.
- Abstract
Background: Cancer treatments can cause significant gastrointestinal (GI) health issues, and negatively affect patient's psychosocial health and quality of life (QOL). Novel, integrative strategies using prebiotics and probiotics have been explored for treating adverse cancer treatment-related side effects. We evaluated the current literature for interventions using prebiotics or probiotics specifically to treat GI and psychosocial health issues in cancer patients and survivors. Methods: Five databases (PubMed, MEDLINE (Ovid), CINHAL, PsychINFO, Web of Science) were searched for studies with prebiotic or probiotic interventions where GI and/or psychosocial health outcomes were measured in adult cancer patients and survivors, and published before September 12th 2021. Results: Twelve studies (N = 974 participants) meeting the inclusion criteria were identified (randomized controlled trials [n = 10], single-group pre-post studies [n = 2]). Ten studies were conducted with patients on active cancer treatment, and 2 studies treated patients after anti-cancer therapies. Three studies used prebiotics, 7 studies used probiotics, and 2 studies used a combination therapy. The most commonly used probiotic strains were from the Lactobacillus genus. There was minimal evidence for prebiotics to improve GI or psychosocial health. Probiotics were associated with significant improvements in abdominal pain (n = 2), gas/bloating (n = 2), and especially diarrhea (n = 5), and with improvements in anxiety (n = 1), depression (n = 1), fatigue (n = 1), and QOL (n = 2). Conclusions: Studies specifically examining effects of prebiotics and probiotics on GI and psychosocial health outcomes are scarce. Probiotic intervention may improve some GI symptoms in cancer patients, and QOL in survivors. Controlled trials that consistently include GI and psychosocial health outcomes are needed.
- Subjects
THERAPEUTIC use of probiotics; CANCER patient psychology; WELL-being; ONLINE information services; CINAHL database; PSYCHOLOGY information storage &; retrieval systems; PREBIOTICS; DIARRHEA; SYSTEMATIC reviews; GUT microbiome; ANTINEOPLASTIC agents; GASTROINTESTINAL diseases; MUSCLE fatigue; TREATMENT effectiveness; MENTAL depression; QUALITY of life; TUMORS; MEDLINE; LACTOBACILLUS; ABDOMINAL pain; ANXIETY; ABDOMINAL bloating; SYMPTOMS
- Publication
Integrative Cancer Therapies, 2021, Vol 20, p1
- ISSN
1534-7354
- Publication type
Article
- DOI
10.1177/15347354211061733