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- Title
Transition‐Metal‐Free Reductive Functionalization of Tertiary Carboxamides and Lactams for α‐Branched Amine Synthesis.
- Authors
Ong, Derek Yiren; Fan, Dongyang; Dixon, Darren J.; Chiba, Shunsuke
- Abstract
A new method for the synthesis of α‐branched amines by reductive functionalization of tertiary carboxamides and lactams is described. The process relies on the efficient and controlled reduction of tertiary amides by a sodium hydride/sodium iodide composite, in situ treatment of the resulting anionic hemiaminal with trimethylsilyl chloride and subsequent coupling with nucleophilic reagents including Grignard reagents and tetrabutylammonium cyanide. The new method exhibits broad functional‐group compatibility, operates under transition‐metal‐free reaction conditions, and is suitable for various synthetic applications on both sub‐millimole and on multigram scales.
- Subjects
CARBOXAMIDES; GRIGNARD reagents; LACTAMS; NUCLEOPHILES; SODIUM hydride; SODIUM iodide
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 29, p12001
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.202004272