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- Title
Highly Selective Artificial Potassium Ion Channels Constructed from Pore-Containing Helical Oligomers.
- Authors
Lang, Chao; Deng, Xiaoli; Yang, Feihu; Yang, Bing; Wang, Wei; Qi, Shuaiwei; Zhang, Xin; Zhang, Chenyang; Dong, Zeyuan; Liu, Junqiu
- Abstract
Potassium ion channels specifically transport K+ ions over Na+ ions across a cell membrane. A queue of four binding sites in the K+ channel pore plays significant roles during highly selective conduction. A kind of aromatic helical oligomer was synthesized that can selectively bind K+ over Na+. By aromatic stacking of helical oligomers, a type of artificial K+ channels with contiguous K+ binding sites was constructed. Such artificial channels exhibited exceptionally high K+/Na+ selectivity ratios during transmembrane ion conduction.
- Subjects
ION channels; OLIGOMERS; CELL membranes; AROMATIC compounds; BINDING sites
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 41, p12842
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201705048