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- Title
Antimonene Quantum Dots: Synthesis and Application as Near-Infrared Photothermal Agents for Effective Cancer Therapy.
- Authors
Tao, Wei; Ji, Xiaoyuan; Xu, Xiaoding; Islam, Mohammad Ariful; Li, Zhongjun; Chen, Si; Saw, Phei Er; Zhang, Han; Bharwani, Zameer; Guo, Zilei; Shi, Jinjun; Farokhzad, Omid C.
- Abstract
Photothermal therapy (PTT) has shown significant potential for cancer therapy. However, developing nanomaterials (NMs)-based photothermal agents (PTAs) with satisfactory photothermal conversion efficacy (PTCE) and biocompatibility remains a key challenge. Herein, a new generation of PTAs based on two-dimensional (2D) antimonene quantum dots (AMQDs) was developed by a novel liquid exfoliation method. Surface modification of AMQDs with polyethylene glycol (PEG) significantly enhanced both biocompatibility and stability in physiological medium. The PEG-coated AMQDs showed a PTCE of 45.5 %, which is higher than many other NMs-based PTAs such as graphene, Au, MoS2, and black phosphorus (BP). The AMQDs-based PTAs also exhibited a unique feature of NIR-induced rapid degradability. Through both in vitro and in vivo studies, the PEG-coated AMQDs demonstrated notable NIR-induced tumor ablation ability. This work is expected to expand the utility of 2D antimonene (AM) to biomedical applications through the development of an entirely novel PTA platform.
- Subjects
QUANTUM dots; NEAR infrared radiation; IRRADIATION; CANCER treatment; CHEMICAL synthesis
- Publication
Angewandte Chemie, 2017, Vol 129, Issue 39, p12058
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201703657