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- Title
Composite Aromatic Boxes for Enzymatic Transformations of Quaternary Ammonium Substrates.
- Authors
Nagy, Gergely N.; Marton, Lívia; Contet, Alicia; Ozohanics, Olivér; Ardelean, Laura ‐ Mihaela; Révész, Ágnes; Vékey, Károly; Irimie, Florin Dan; Vial, Henri; Cerdan, Rachel; Vértessy, Beáta G.
- Abstract
Cation-π interactions to cognate ligands in enzymes have key roles in ligand binding and enzymatic catalysis. We have deciphered the key functional role of both charged and aromatic residues within the choline binding subsite of CTP:phosphocholine cytidylyltransferase and choline kinase from Plasmodium falciparum. Comparison of quaternary ammonium binding site structures revealed a general composite aromatic box pattern of enzyme recognition sites, well distinguished from the aromatic box recognition site of receptors.
- Subjects
COMPOSITE materials; QUATERNARY ammonium compounds; CATIONS; ENZYMES; LIGAND binding (Biochemistry); CATALYSIS
- Publication
Angewandte Chemie, 2014, Vol 126, Issue 49, p13689
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201408246