We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The prevalence and clinical presentation of Hirschsprung's disease in preterm infants: a systematic review and meta-analysis.
- Authors
Chen, Yi; Yuan, Xiaojian; Li, Yonglin; Wu, Shannan; Miao, Xuefeng; Gong, Junfei; Huang, Yuntao
- Abstract
<bold>Purpose: </bold>Hirschsprung's disease (HD) is a rare occurrence in premature infants, and the exact prevalence varying across studies. Thus, we conducted this study to determine the prevalence of and clinical presentation of HD in preterm infants.<bold>Methods: </bold>The PubMed, EmBase, and Cochrane library databases were searched for eligible studies throughout May 2021. The pooled incidence with 95% confidence interval (CI) was calculated using the random-effects model.<bold>Results: </bold>Thirty studies involved 4,557 children with HD were included. The pooled proportion of HD patients who were preterm infants was 7% (95% CI 5-8%; P < 0.001); the sensitivity analysis indicated that the pooled prevalence of preterm infants with HD ranged from 5.0% to 5.6%. Moreover, the pooled incidence of abdominal distention in HD patients was 83% (P < 0.001), that of vomiting was 61% (P < 0.001), that of bilious vomiting was 54% (P < 0.001), that of delayed meconium passage was 48% (P < 0.001), that of constipation was 44% (P < 0.001), and that of enterocolitis was 13% (P < 0.001).<bold>Conclusions: </bold>This study reported the prevalence of HD patients who were preterm infants, and the most common presentations were abdominal distention, vomiting, bilious vomiting, delayed meconium passage, constipation, and enterocolitis.
- Subjects
ENTEROCOLITIS; RESEARCH; META-analysis; CONSTIPATION; RESEARCH methodology; SYSTEMATIC reviews; EVALUATION research; COMPARATIVE studies; DISEASE prevalence; RESEARCH funding; HIRSCHSPRUNG'S disease; DISEASE complications
- Publication
Pediatric Surgery International, 2022, Vol 38, Issue 4, p523
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-021-05054-2