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- Title
Matriderm® 1 mm versus Integra® Single Layer 1.3 mm for one-step closure of full thickness skin defects: a comparative experimental study in rats.
- Authors
Böttcher-Haberzeth S; Biedermann T; Schiestl C; Hartmann-Fritsch F; Schneider J; Reichmann E; Meuli M; Böttcher-Haberzeth, Sophie; Biedermann, Thomas; Schiestl, Clemens; Hartmann-Fritsch, Fabienne; Schneider, Jörg; Reichmann, Ernst; Meuli, Martin
- Abstract
<bold>Purpose: </bold>Dermal templates, such as Matriderm® and Integra®, are widely used in plastic and reconstructive surgery, often as two-step procedures. A recent development is the application of thin dermal templates covered with split thickness skin grafts in one-step procedures. In this experimental study, we compare the two thin matrices Matriderm® 1 mm and Integra® Single Layer in a one-step procedure with particular focus on neodermis formation.<bold>Methods: </bold>Matriderm® 1 mm and Integra® Dermal Regeneration Template-Single Layer (1.3 mm) were compared in a rat model. In three groups of five animals each, a full thickness wound was covered with (a) Matriderm® 1 mm and neonatal rat epidermis, (b) Integra® Single Layer and neonatal rat epidermis, or, (c) neonatal rat epidermis only (control). Histological sections 2 weeks post transplantation were analyzed with regard to take of template and epidermis, neodermal thickness, collagen deposition, vascularization, and inflammatory response.<bold>Results: </bold>Take of both templates was complete in all animals. The Matriderm®-based neodermis was thinner but showed a higher cell density than the Integra®-based neodermis. The other parameters were similar in both matrices.<bold>Conclusion: </bold>The two templates demonstrate a comparable biological behavior early after transplantation. The only difference was found regarding neodermal thickness, probably resulting from faster degradation of Matriderm®. These preliminary data suggest that both dermal templates appear similarly suitable for transplantation in a one-step procedure.
- Publication
Pediatric Surgery International, 2012, Vol 28, Issue 2, p171
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-011-2990-5