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- Title
A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.
- Authors
Taniguchi, Rumi; Koyano, Shin; Suzutani, Tatsuo; Goishi, Keiji; Ito, Yushi; Morioka, Ichiro; Nakamura, Hiroyuki; Yamada, Hideto; Oka, Akira; Inoue, Naoki
- Abstract
The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, in 87 cCMV cases, and found that there was a significant association between cCMV disease and a single nucleotide polymorphism, Thr72Ala, in NKG2D.
- Subjects
CYTOMEGALOVIRUS diseases; ALLELES; CONFIDENCE intervals; FISHER exact test; FLOW cytometry; GENETIC polymorphisms; KILLER cells; LIGANDS (Biochemistry); LONGITUDINAL method; PROBABILITY theory; RESEARCH funding; DATA analysis software; GENETICS; DISEASE risk factors
- Publication
Infection, 2015, Vol 43, Issue 3, p353
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-015-0774-x