We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Suboptimal performance of LI-RADS v2018 on gadoxetic acid–enhanced MRI for detecting hepatocellular carcinoma in liver transplant candidates.
- Authors
Oh, Na Eun; Choi, Sang Hyun; Kim, Sehee; Lee, Habeen; Jang, Hyeon Ji; Byun, Jae Ho; Won, Hyung Jin; Shin, Yong Moon
- Abstract
Objectives: To evaluate the diagnostic performance for hepatocellular carcinoma (HCC) detection of the Liver Imaging Reporting and Data System (LI-RADS) version 2018 on gadoxetic acid–enhanced MRI, comparing liver transplant candidates (LT group) with patients who underwent surgical resection (SR group), and to determine significant clinical factors for diagnostic performance of LI-RADS v2018. Methods: Patients who underwent gadoxetic acid–enhanced MRI and subsequent SR or LT for HCC were retrospectively included between January 2019 and December 2020. The sensitivity and specificity of LI-RADS LR-5 for HCC were compared between the two groups using generalized estimating equations. The accuracy of patient allocation according to the Milan criteria was calculated for the LT group. Univariable and multivariable logistic regression analyses were performed to determine significant clinical factors associated with the sensitivity of LI-RADS. Results: Of the 281 patients, 237 were assigned to the SR group, and 44 were assigned to the LT group. The LT group showed significantly lower per-patient (48.5% vs. 79.6%, p <.001) and per-lesion sensitivity (31.0% vs. 75.9%, p <.001) than the SR group, whereas no significant difference in both per-patient (100.0% vs. 91.7%, p >.99) and per-lesion specificities (100.0% vs. 94.1%, p >.99). The accuracy of patient allocation was 50.0%. Sensitivity was significantly lower in patients with a smaller lesion size (p <.001), a larger lesion number (p =.002), and a higher Child–Pugh score (p =.009). Conclusion: LI-RADS v2018 on gadoxetic acid–enhanced MRI might be insufficient in liver transplant candidates and other diagnostic imaging tests should be considered in patients with these significant clinical factors. Clinical relevance statement: In liver transplant candidates with a smaller lesion size, a larger lesion number, and a higher Child–Pugh score, imaging tests other than gadoxetic acid–enhanced MRI may be clinically useful to determine the transplant eligibility. Key Points: • The sensitivity of the Liver Imaging Reporting and Data System (LI-RADS) was lower in liver transplant candidates than in those who underwent surgical resection. • With the use of gadoxetic acid–enhanced MRI, the accuracy of patient allocation for liver transplantation on the basis of the Milan criteria was suboptimal. • The sensitivity of LI-RADS v2018 was significantly associated with lesion size, lesion number, and Child–Pugh classification.
- Subjects
LIVER transplantation; HEPATOCELLULAR carcinoma; ALLOCATION of organs, tissues, etc.; MAGNETIC resonance imaging; GENERALIZED estimating equations
- Publication
European Radiology, 2024, Vol 34, Issue 1, p465
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-023-10014-6