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- Title
Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson's Disease.
- Authors
Xueying, Ling; Zhongping, Zhang; Zhoushe, Zhao; Li, Guo; Yongjin, Tang; Changzheng, Shi; Zhifeng, Zhou; Peihao, Chen; Hao, Xu; Li, Huang
- Abstract
Objectives: To assess brain damage in Parkinson's disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values. Methods: Eighteen PD patients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm) and 15 b-values (0-5,000 s/mm). Standard ADC (ADC) maps were calculated from standard b-values, while maps of pure diffusion coefficients (D), pseudo-diffusion coefficients (D), and ultra-high ADCs (ADC) were calculated from the 15 b-values using a tri-component model. In this model, D and D values were quantified with a bi-exponential equation using b-values less than 2,000 s/mm, while ADC was quantified by fitting the signals at ultra-high b-values (2,000-5,000 s/mm) to the mono-exponential equation. ADC, ADC, D, and D of the globus pallidus (GP), putamen (P), and substantia nigra (SN) were compared between PD patients and normal control subjects. Results: ADC of the GP, P, and SN was significantly lower in PD patients than those in control subjects ( P < 0.001), while ADC, D, and D of the GP, P and SN were not different between the two groups ( P > 0.05). Conclusions: ADC may be a useful measurement for evaluating brain damage in PD patients. Key Points: • DWI with ultra- high b- values may provide new insight into Parkinson' s disease pathology • ADC calculated using ultra- high b- values is different between PD and controls • ADC may be associated with water transportation by aquaporins
- Subjects
PARKINSON'S disease diagnosis; DIFFUSION coefficients; DIFFUSION magnetic resonance imaging; SUBSTANTIA nigra; BRAIN damage; GLOBUS pallidus
- Publication
European Radiology, 2015, Vol 25, Issue 9, p2593
- ISSN
0938-7994
- Publication type
Article
- DOI
10.1007/s00330-015-3678-3