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- Title
Utilization of extended donor criteria in liver transplantation: a comprehensive review of the literature.
- Authors
Nickkholgh, Arash; Weitz, Jürgen; Encke, Jens; Sauer, Peter; Mehrabi, Arianeb; Büchler, Markus W.; Schmidt, Jan; Schemmer, Peter
- Abstract
Organ shortage has driven many transplant programs to extend their criteria to accept donors. The goal of the present work is to further characterize the most important extended donor criteria (EDC) in liver transplantation and to identify factors that impact outcomes for this type of grafts through a comprehensive review of the most recent findings and current opinions. Age, steatosis, positive viral hepatitis serology, intensive care unit stay, and history of malignancy in donor have been the matter of substantial debate in recent years and are therefore discussed in further detail here. Cold and warm ischemic times have also been discussed separately as they have been identified as important independent risk factors for mortality. The use of grafts with EDC provides an immediate expansion of the donor pool. However, in order to optimize effective utilization of EDC, attempts should be made to carefully match the most appropriate graft-recipient pair.
- Subjects
ORGAN donors; LIVER transplantation; VIRAL hepatitis; SEROLOGY; INTENSIVE care units
- Publication
Nephrology Dialysis Transplantation, 2007, Vol 22, Issue suppl_8, pviii29
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfm654