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- Title
The antimicrobial activity and beta-lactamase stability of cefpirome, a new fourth-generation cephalosporin in comparison with other agents.
- Authors
Cheng, A F; Ling, T K; Lam, A W; Fung, K S; Wise, R
- Abstract
The antimicrobial activity of cefpirome was compared with amoxycillin/clavulanic acid, ampicillin/sulbactam, cefuroxime, ceftazidime, gentamicin and amikacin against 743 non-duplicate clinical isolates. MIC50 and MIC90 showed that the antibiotic was active against both Gram-negative and Gram-positive organisms. Cefpirome was highly active against most of the Enterobacteriaceae, including indole-positive Proteus spp., Aeromonas spp. (MIC < or = 1 mg/L) and Salmonella spp. (MIC < or = 0.5 mg/L). Neisseria gonorrhoeae and Haemophilus influenzae (including beta-lactamase producers) were all susceptible, with MIC less than 0.5 and 0.25 mg/L respectively. Cefpirome was more active than cefuroxime and ceftazidime against Campylobacter spp. (MIC < or = 2 mg/L), but less active than ceftazidime against Pseudomonas aeruginosa. Cefpirome was active against Streptococcus pneumoniae. Streptococcus bovis and coagulase-negative staphylococci (MIC < or = 0.5 mg/L) and methicillin-sensitive Staphylococcus aureus (MIC < or = 2 mg/L). Methicillin-resistant S. aureus, Gram-positive and Gram-negative anaerobes were resistant to cefpirome. The stability of cefpirome to TEM-1, TEM-2, PSE-1, SHV-1 and the chromosomal-mediated P99 and K-1 beta-lactamases was comparable to ceftazidime.
- Subjects
ANAEROBIC bacteria; ANTIBIOTICS; BACTERIA; BACTERIAL diseases; CEPHALOSPORINS; COMPARATIVE studies; GRAM-negative bacteria; GRAM-positive bacteria; HYDROLASES; RESEARCH methodology; MEDICAL cooperation; METHICILLIN resistance; MICROBIAL sensitivity tests; RESEARCH; STAPHYLOCOCCUS aureus; XANTHOMONAS; EVALUATION research; CITROBACTER; GRAM-negative aerobic bacteria; PHARMACODYNAMICS
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1993, Vol 31, Issue 5, p699
- ISSN
0305-7453
- Publication type
journal article