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- Title
Pharmacokinetics of teicoplanin in the elderly.
- Authors
Rosina, R.; Villa, G.; Danese, A.; Cavenaghi, L.; Picardi, L.; Salvadeo, A.
- Abstract
The phannacokinetic profile of teicoplanin was studied in 12 elderly patients with a moderate degree of renal impairment (mean creatinine clearance, 51·3 ml/h/kg before treatment), after a single 6 mg/kg iv dose. Pharmacokinetic parameters were estimated both by a three-compartment open pharmacokinetic model and by non-compartmental analysis; peak plasma levels, 15 min after administration, averaged 45 mg/l. The half-lives of the two distributive phases were 0·39 and 7·3 h, respectively. The elimination half-life averaged 107 h, with similar estimates obtained from the three-compartment analysis and from urinary data. The volume of distribution from the central compartment was 009 l/kg while the volumes of distribution at steady state and during the elimination phase were 1·3 and 1·6 I/kg, respectively. The total teicoplanin clearance averaged 10·6 ml/h/kg, with renal clearance accounting for about 40% of the total. There was a linear correlation between teicoplanin total or renal clearance and endogenous creatinine clearance. The average total recovery of teicoplanin in urine over eight days was 28%. There were no local or systemic adverse reactions to teicoplanin.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1988, Vol 21, Issue suppl_A, p39
- ISSN
0305-7453
- Publication type
Article