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- Title
Pharmacokinetics of roxitharomycin in paediatrics.
- Authors
Bégué, P.; Kafetzis, D. A.; Albin, H.; Safran, Ch.
- Abstract
Macrolides are well known for their high lipid solubility and good tissue penetration. The pharmacokinetic properties of roxithromyrin, a new semisynthetic macrolide, appear to be very interesting in healthy adult patients. Five paediatric pharmacokinetic studies are summarized and show that the pharmacokinetic properties of roxithromycin in paediatrics are very similar to those previously reported in adults and suggest that the same dose every 12 h is appropriate in paediatrics, 2.5 mg/kg. The diffusion of roxithromycin into upper respiratory tract tissues appears to be good in children.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1987, Vol 20, Issue suppl_B, p101
- ISSN
0305-7453
- Publication type
Article