We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections.
- Authors
Jones, B. M.; Geary, I.; Lee, M. E.; Duerden, B. I.
- Abstract
The in-vitro activity of the quinolone derivative pefloxacin was compared with that of three other quinolones, five β-lactam antibiotics and three aminoglycosides against 367 isolates from hospital patients and from out-patients with genitourinary infections. MIC of pefloxacin and norfloxacin for each strain was the same; that of ciprofloxacin was a little lower. All strains except were resistant to nalidixic acid. Pefloxacin was highly active against (39 strains; MIC 1.0 mg/l) and most strains of coagulase-negative staphylococci (56; 4 mg/l), (50; 0.25 mg/l), other enterobacteria (33; 1.0 mg/l) and 6; 0.25 mg/l). With spp. (total 78; 64 mg/l), the fragilis group (23) and the fusobacteria (19) were resistant, but the melaninogenicus-oralis group (31; range 0.06- > 64 mg/l) and (22; 0.125- > 64 mg/l) gave variable results. Amongst genitourinary isolates, (15) and (34) were sensitive (<0.06 mg/l) but (25) and spp. (11) were resistant (32 mg/l). Pefloxacin was more active than ceftazidime, cefotaxime, ceftizoxime, latamoxef and piperacillin against and coagulase-negative staphylococci and than gentamicin, tobramycin and amikacin against coagulase-negative staphylococci. No enterobacteria or pseudomonads were resistant to perfloxacin or other quinolones, whereas some were resistant to β-lactams and aminoglycosides.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1986, Vol 17, Issue 6, p739
- ISSN
0305-7453
- Publication type
Article