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- Title
Concurrent Neurological Involvement in Chronic Lymphocytic Leukemia: A Rare Case With Brain and Spinal Manifestations.
- Authors
Saiedi, Emad; Mahmoud-Nejad, Shahab; Mohazzab-Torabi, Saman; Ganjeifar, Babak
- Abstract
Background and Importance: Chronic lymphocytic leukemia (CLL) stands as the predominant form of lymphoproliferative ailment in America. Despite its rarity, CLL invasion into the central nervous system (CNS) is known to have varied consequences. Furthermore, it is an exceptional occurrence for symptomatic CNS lesions to serve as a foremost indication of undiagnosed CLL. Case Presentation: In this case study, a 71-year-old male patient with CLL medical history presented to our center due to CNS involvement and symptoms of headache and weakness in the lower extremities. Subsequent magnetic resonance imaging (MRI) evaluation identified a "ring or target sign" in both the temporal lobe and intramedullary spinal cord at the T9-T10 level. A surgical procedure was performed for resection of the temporal lesion, which histologically confirmed CLL. Conclusion: To conclude, the initial manifestation of CNS involvement in chronic lymphocytic leukemia is rare and not biased toward any specific demographic factors, such as age, gender, or ethnicity. Such occurrence can take place at any stage of CLL. Thus, it is crucial to consider this likelihood when patients with a prior history of CLL show neurological symptoms.
- Subjects
AMERICA; CHRONIC lymphocytic leukemia; CENTRAL nervous system; MAGNETIC resonance imaging; SPINAL cord tumors; TEMPORAL lobe; SPINAL cord; CHRONIC leukemia
- Publication
Iranian Journal of Neurosurgery, 2023, Vol 9, p1
- ISSN
2423-6497
- Publication type
Article
- DOI
10.32598/irjns.9.28