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- Title
Synthesis and in vivo fungicidal activity of some new quinoline derivatives against rice blast.
- Authors
Liu, Xing Hai; Fang, Yue Ming; Xie, Feng; Zhang, Rui Rui; Shen, Zhong Hua; Tan, Chen Xia; Weng, Jian Quan; Xu, Tian Ming; Huang, Hong Ying
- Abstract
BACKGROUND Quinoline derivatives possess excellent fungicidal activity against rice blast, but quinoline derivatives have not been thoroughly explored as fungicides. In the process of designing new fungicides, the 1,1,1,2,3,3,3-heptafluoropropan-2-yl group was introduced in order to find new structure quinoline derivatives. RESULTS Seventeen new quinoline derivatives containing 1,1,1,2,3,3,3-heptafluoropropan-2-yl moiety were designed and synthesised. In vivo fungicidal activities of these compounds were tested against rice blast. Some of the compounds provided effective control at 100 mg L−1, and a few compounds were effective at 10 mg L−1. Furthermore, a density functional theory study established the structure-activity relationships of the synthesised compounds. CONCLUSION Quinoline derivatives, especially benzyl (2,3,8-trimethyl-6-(perfluoropropan-2-yl)quinolin-4-yl) carbonate, which possess good control effective against rice blast and cucumber powdery mildew, may become new lead compounds for the development of fungicides with further structure modification. © 2017 Society of Chemical Industry
- Subjects
QUINOLINE; FUNGICIDES &; the environment; CHEMICAL synthesis; RICE blast disease prevention
- Publication
Pest Management Science, 2017, Vol 73, Issue 9, p1900
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.4556