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- Title
Design, synthesis and bioactivity evaluation of novel benzophenone hydrazone derivatives.
- Authors
Li, Wen‐Qun; Zhang, Zhi‐Jun; Nan, Xiang; Liu, Ying‐Qian; Hu, Guan‐Fang; Yu, Hai‐Tao; Zhao, Xiao‐Bo; Wu, Dan; Yan, Li‐Ting
- Abstract
BACKGROUND Benzophenone hydrazone derivatives are among the most important classes of synthetic insecticides. In an effort to discover new molecules with good insecticidal/acaricidal activities, a series of novel benzophenone hydrazone N-acylated thiourea and urea derivatives was synthesized and bioassayed. RESULTS All of these compounds exhibited excellent bioactivities against T. cinnabarinus and B. brassicae, especially towards T. cinnabarinus with LC50 values ranging from 0.305 to 2.036 mmol L-1. Moreover, the acaricidal activities against T. cinnabarinus of compounds 8a-i, 12b-f and 12h were 2.5-5.5-fold that of parent molecule 3 based on the LC50 value. CONCLUSION Based on the observed bioactivities, the structure-activity relationship of these analogs was also discussed. Structure-activity relationships provided information that could direct further investigation on structure modification. Our studies indicated that benzophenone hydrazone N-acylated thiourea and urea derivatives could be used as potential lead compounds for developing novel acaricides and insecticides. © 2013 Society of Chemical Industry
- Subjects
CHEMICAL synthesis; BENZOPHENONES; HYDRAZONE derivatives; CHEMICAL derivatives; INSECTICIDES; BIOLOGICAL assay
- Publication
Pest Management Science, 2014, Vol 70, Issue 4, p667
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.3607