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- Title
Quantitative structure-activity studies of insect growth regulators: XVIII. Effects of substituents on the aromatic moiety of dibenzoylhydrazines on larvicidal activity against the Colorado potato beetle Leptinotarsa decemlineata.
- Authors
Nakagawa, Yoshiaki; Smagghe, Guy; Van Paemel, Marleen; Tirry, Luc; Fujita, Toshio
- Abstract
Larvicidal activity against the Colorado potato beetle Leptinotarsa decemlineata (Say) was measured for a series of 2V-tert-butyl-dibenzoylhydrazines having various substituents on the benzoyl (A-ring) moiety nearer to the tert-butyl group, with the other benzoyl (B-ring) moiety being unsubstituted. The effects of these substituent on the larvicidal activity were analyzed using classical quantitative structure-activity relationship (QSAR) procedures. The effects of substituents on the A-ring moiety on larvicidal activity were entirely different from those against the lepidopteran rice stem borer Chilo suppressalis (Walker) previously reported. Position-specific steric and hydrophobic effects, as well as certain substitution patterns, were likely to participate in modifying the larvicidal activity. The activity of para-substituted compounds was generally lower than that of un-, ortho- and meta-substituted compounds. Most multi-substituted compounds showed an activity equivalent to or lower than that of the unsubstituted compound. Among 46 compounds tested, the 2-sec-butoxy analogue was most potent against L decemlineata, although this compound had previously been shown to be only weakly active against C suppressalis.
- Subjects
COLORADO potato beetle; QSAR models; STEM borers; ECDYSONE; PEST control; INSECT larvae
- Publication
Pest Management Science, 2001, Vol 57, Issue 9, p858
- ISSN
1526-498X
- Publication type
Article
- DOI
10.1002/ps.376