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- Title
Structural determinants of T-cell receptor bias in immunity.
- Authors
Turner, Stephen J.; Doherty, Peter C.; McCluskey, James; Rossjohn, Jamie
- Abstract
Antigen-specific T-cell responses induced by infection, transplantation, autoimmunity or hypersensitivity are characterized by cells expressing biased profiles of T-cell receptors (TCRs) that are selected from a diverse, naive repertoire. Here, we review the evidence for these TCR biases, focusing on crystallographic analysis of the structural constraints that determine the binding of a TCR to its ligand and the persistence of certain TCRs in an immune repertoire. We discuss the ways in which diversity in a selected TCR repertoire can contribute to protective immunity and the implications of this for vaccine design and immunotherapy.
- Subjects
IMMUNE response; ANTIGENS; T cell receptors; CRYSTALLOGRAPHY; LIGANDS (Biochemistry); VACCINES; IMMUNOTHERAPY
- Publication
Nature Reviews Immunology, 2006, Vol 6, Issue 12, p883
- ISSN
1474-1733
- Publication type
Article
- DOI
10.1038/nri1977