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- Title
Determination of tetrahydrocannabinol, cannabidiol and cannabinol in cosmetics by ultra performance liquid chromatography-triple quadrupole mass spectrometry.
- Authors
CHEN Nian-nian; ZHOU Ying; HAN Li; DENG Xiao-jun
- Abstract
A method for simultaneous determination of three cannabinoids in cosmetics by ultra performance liquid chromatography -triple quadrupole mass spectrometry was established. The samples were extracted by acetonitrile, purified by QuEChERS method, and then separated by Athena C18-WP column (2.1 mm x 150 mm, 3 μm), using acetonitrile- water as mobile phase. By optimizing the elution gradient of mobile phase, the separation for the three cannabinoids was well achieved. The linear correlation coefficients (r²) of cannabinol (CBN) and cannabidiol (CBD) were both greater than 0.999 in the concentration range of 0.1~10 μg/L, and the linear correlation coefficient of tetrahydrocannabinol (THC) in the concentration range of 1~100 μg/L was greater than 0.999. When 3 S/N was used as the limit of detection (LOD) and 10 S/N was used as the limit of quantification (LOQ), the LOD of the three cannabinoids was 0.3~3 μg/kg, and the LOQ was 1~10 μg/kg. The matrix matching method was used to quantify the three cannabinoids simultaneously. The recovery rates of the three cannabinoids were 82.3%~108.1% at the standard addition levels of 1 LOQ, 2 LOQ and 10 LOQ. The relative standard deviation (RSD) was 1.2%~5.8% (n=6). The results show that the method has good stability and high sensitivity, and is suitable for simultaneous determination of the three cannabinoids in common cosmetics.
- Publication
Detergent & Cosmetics, 2022, Vol 45, Issue 5, p18
- ISSN
1006-7264
- Publication type
Article
- DOI
10.3969/j.issn.1006-7264.2022.05.005