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- Title
Sperm mitochondrial DNA copy number in relation to semen quality: A cross‐sectional study of 1164 potential sperm donors.
- Authors
Sun, Bin; Hou, Jian; Ye, Yi‐Xiang; Chen, Heng‐Gui; Duan, Peng; Chen, Ying‐Jun; Xiong, Cheng‐Liang; Wang, Yi‐Xin; Pan, An
- Abstract
Objective: To investigate the association between mitochondrial DNA copy number (mtDNAcn) and semen quality. Design: A cross‐sectional study. Setting: Hubei Province Human Sperm Bank of China (from April 2017 to July 2018). Population: A total of 1164 healthy male sperm donors with 5739 specimens. Main outcome measures: Real‐time quantitative polymerase chain reaction (RT‐PCR) was used to measure sperm mtDNAcn. We also determined semen volume, concentration and motility parameters (progressive motility, nonprogressive motility and immotility). Methods: Mixed‐effect models and general linear models were uses. Results: After adjusting for relevant confounding factors, mixed‐effect models revealed diminished sperm motility (progressive and total), concentration, and total count across the quartiles of mtDNAcn (all P < 0.05). Compared with men in the lowest quartile, men in the highest quartile of mtDNAcn had lower progressive sperm motility, total motility, concentration and total count of −8.9% (95% CI −12.7% to −5.0%), −8.0% (95% CI −11.6% to −4.4%), −42.8% (95% CI −47.7% to −37.4%), and − 44.3% (95% CI −50.1% to −37.7%), respectively. These inverse dose–response relationships were further confirmed in the cubic spline models, where mtDNAcn was modelled as a continuous variable. Conclusions: We found that mtDNAcn was inversely associated with semen quality in a dose‐dependent manner. Our results provide novel clues that sperm mtDNAcn may serve as a useful predictor of human semen characteristics. Sperm mitochondrial DNA copy number was markedly associated with diminished sperm motility (progressive and total), concentration and total count. Sperm mitochondrial DNA copy number was markedly associated with diminished sperm motility (progressive and total), concentration and total count.
- Subjects
HUBEI Sheng (China); SEMEN analysis; MITOCHONDRIAL DNA; SPERM donation; SPERMATOZOA; SPERM motility
- Publication
BJOG: An International Journal of Obstetrics & Gynaecology, 2022, Vol 129, Issue 13, p2098
- ISSN
1470-0328
- Publication type
Article
- DOI
10.1111/1471-0528.17139