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- Title
Breakthrough of solid tumor treatment: CAR-NK immunotherapy.
- Authors
Wang, Wenkang; Liu, Yang; He, Zhen; Li, Lifeng; Liu, Senbo; Jiang, Mingqiang; Zhao, Bing; Deng, Meng; Wang, Wendong; Mi, Xuefang; Sun, Zhenqiang; Ge, Xin
- Abstract
As the latest and most anticipated method of tumor immunotherapy, CAR-NK therapy has received increasing attention in recent years, and its safety and high efficiency have irreplaceable advantages over CAR-T. Current research focuses on the application of CAR-NK in hematological tumors, while there are fewer studies on solid tumor. This article reviews the process of constructing CAR-NK, the effects of hypoxia and metabolic factors, NK cell surface receptors, cytokines, and exosomes on the efficacy of CAR-NK in solid tumor, and the role of CAR-NK in various solid tumor. The mechanism of action and the research status of the potential of CAR-NK in the treatment of solid tumor in clinical practice, and put forward the advantages, limitations and future problems of CAR-NK in the treatment of solid tumor.
- Subjects
TUMOR treatment; CELL receptors; KILLER cells; IMMUNOTHERAPY; CYTOKINE receptors
- Publication
Cell Death Discovery, 2024, Vol 10, Issue 1, p1
- ISSN
2058-7716
- Publication type
Article
- DOI
10.1038/s41420-024-01815-9