We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Creatine Supplementation (3 g/d) and Bone Health in Older Women: A 2-Year, Randomized, Placebo-Controlled Trial.
- Authors
Sales, Lucas Peixoto; Pinto, Ana Jéssica; Rodrigues, Samara Ferrari; Alvarenga, Jackeline Couto; Gonçalves, Natalia; Sampaio-Barros, Marília M; Benatti, Fabiana Braga; Gualano, Bruno; Pereira, Rosa Maria Rodrigues; Rodrigues Pereira, Rosa Maria
- Abstract
<bold>Background: </bold>Creatine supplementation could be a nonexpensive, safe, and effective dietary intervention to counteract bone loss. The aim of this study was to investigate whether long-term creatine supplementation can improve bone health in older, postmenopausal women.<bold>Methods: </bold>A double-blind, placebo-controlled, parallel-group, randomized trial was conducted between November 2011 and December 2017 in Sao Paulo, Brazil. Two hundred postmenopausal women with osteopenia were randomly allocated to receive either creatine monohydrate (3 g/d) or placebo for 2 years. At baseline and after 12 and 24 months, we assessed areal bone mineral density (aBMD; primary outcome), lean and fat mass (through dual X-ray absorptiometry), volumetric BMD and bone microarchitecture parameters, biochemical bone markers, physical function and strength, and the number of falls and fractures. Possible adverse effects were self-reported.<bold>Results: </bold>Lumbar spine (p < .001), femoral neck (p < .001), and total femur aBMD (p = .032) decreased across time; however, no interaction effect was observed (all p > .050). Bone markers, microarchitecture parameters, and the number of falls/fractures were not changed with creatine (all p > .050). Lean mass and appendicular skeletal muscle mass increased throughout the intervention (p < .001), with no additive effect of creatine (p = .731 and p = .397, respectively). Creatine did not affect health-related laboratory parameters.<bold>Conclusion: </bold>Creatine supplementation more than 2 years did not improve bone health in older, postmenopausal women with osteopenia, nor did it affect lean mass or muscle function in this population. This refutes the long-lasting notion that this dietary supplement alone has osteogenic or anabolic properties in the long run.<bold>Clinical Trial Registry: </bold>Clinicaltrials.gov: NCT: 01472393.
- Subjects
DELHI (India); SAO Paulo (Brazil); BRAZIL; DUAL-energy X-ray absorptiometry; BONES; OLDER women; CREATINE; FEMUR neck; BONE density; WOMEN'S health; OSTEOPOROSIS prevention; RESEARCH; PHOTON absorptiometry; OSTEOPENIA; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RANDOMIZED controlled trials; POSTMENOPAUSE; BLIND experiment; MUSCLE strength; ACCIDENTAL falls; STATISTICAL sampling; BONE fractures
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2020, Vol 75, Issue 5, p931
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz162