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- Title
ER、PR、CA-153、Ki-67 的表达与乳腺癌临床病理特征及预后的 相关性研究.
- Authors
黄增光; 荣震; 石玮; 李春姗; 陈莲
- Abstract
Objectivo: To study the correlation between the expression of estrogen receptor (ER). progesterone receptor (PR), carbohydrate antigen-153 (CA-153), ki-67 and clinic opathological features and prognosis of breast cancer. Methods: A total of 190 patients with breast cancer, who were treated in First Affiliated Hospital of Guangxi University of Chinese Medicine from March 2015 to April 2017, were selected as research subjects. The expression of ER. PR and ki-67 were detected by inimunohistochemistry, the expression of CA-153 was detected by enzyme-linked immunosorbent assay. The relationship between the expression of the above four indexes and the clinicopathological features was analyzed, and the correlation between the indexes was analyzed. Results: The positive rates of ER and PR in breast cancer tissues with lymph node metastasis were significantly higher than those without lyinph node metastasis, and the difference was statistically significant (P<0.05). The positive rate of CA-153 in breast cancer tissues with tumor size >2 cm, TNM stage III-IV stage and lymph node metastatic were higher than that with tumor size ≥ 2 cm. TNM stage I-II stage, and without lyinph node metastasis, the difference was statistically significant (P<0.05); there was no significant difference in the positive rate of CA-153 in the breast cancer tissues of different ages (P>0.05). The positive rate of Ki-67 in breast cancer tissues with TNM stage DI-IV stage and lymph node metastasis was significantly higher than that with TNM stage I-II stage and without lyniph node metastasis, the difference was statistically significant (P<0.05); there was no significant difference in the positive rate of Ki-67 in breast cancer tissues of different age and tumor size (P>0.05). The Pearson correlation analysis showed that the expression of ER, PR, CA-153 and Ki-67 were positively correlated in breast cancer (Pc-Xt.05). Conclusion: In clinical work, combination of detecting the expression of ER, PR. CA-153 and Ki-67 can effectively predict the severity and metastasis of patients with breast cancer, which is wormy of clinical application.
- Publication
Progress in Modern Biomedicine, 2018, Vol 18, Issue 10, p1948
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2018.10.029