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- Title
晚期非小细胞肺癌患者外周血 Th17 细胞和 Treg 细胞水平与化疗敏感相关性研究.
- Authors
张剑波; 曹玫; 汪智英; 陈杰; 房俊
- Abstract
Objective: To research the correlation of the level of peripheral blood Th17 cells and Treg cells and chemotherapy sensitivity in advanced non-small cell lung cancer patients. Methods: We selected 78 cases of advanced non-small cell lung cancer as case group, and 40 cases of healthy people as control group at the same time. Patients with lung cancer in case group were treated with TP regimen, and got flow cytometry detection of peripheral blood cell count Th17 (CD4+y-IFN +), Treg (CD4+CD25+ Foxp3+) level before and after chemotherapy. After two courses of chemotherapy, chemotherapy effect and sensitivity was evaluated. Results: The peripheral blood level of Th17 cells and Treg cells in case group was obviously higher than in control group, and the difference was statistically significant (P<0.05). Before the first and second chemotherapy, the peripheral blood levels of Th17 cells and Treg cells were higher than the levels after chemotherapy in case group, and the difference was statistically significant (P<0.05). According to the WHO criterion on chemotherapy effect of entity tumor, CR regarded as sensitive to chemotherapy group, and PR, SD as effective chemotherapy, PD as invalid chemotherapy, all cases were divided into chemotherapy-sensitive group, effective group and invalid group. The before the first and second chemotherapy, the levels of peripheral blood Th17 cells and Treg cells were higher in sensitive group than in effective group and ineffective group, and higher in effective group than in invalid group. Differences were statistically significant (P<0.05). Conclusion: The patients with advanced lung cancer had increased peripheral blood level of Th17 cells and Treg cells. The level of Th17 cells and Treg cells and chemotherapy sensitivity showed a certain positive correlation.
- Publication
Progress in Modern Biomedicine, 2017, Vol 17, Issue 7, p1471
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2017.08.016