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- Title
Alcohol-Inactivated Autograft Replantation with Joint Preservation in the Management of Osteosarcoma of the Distal Femur: A Preliminary Study.
- Authors
Yu, Xiu-Chun; Xu, Song-Feng; Xu, Ming; Liu, Xiao-Ping; Song, Ruo-Xian; Fu, Zhi-Hou
- Abstract
SummaryAim: To evaluate clinical outcomes in patients who underwent alcohol-inactivated autograft replantation with joint preservation for the treatment of osteosarcoma of the distal femur. Patients and Methods: 10 patients (7 men, 3 women; mean age: 20.1 years) were treated. 9 patients had Enneking stage IIb tumors and 1 patient had stage III. The mean follow-up time was 34 months. All patients obtained first-stage healing. Results: 1 patient died of local recurrence and multiple metastases 13 months after surgery; 3 patients died of multiple metastases 9, 12, and 24 months after surgery, respectively. 3 patients required second surgery because of fracture of the inactivated autograft, 1 patient died 6 months later, 1 patient experienced bony healing 4 months later with no further complications, and 1 patient required subsequent open reduction and bone implantation with internal fixation (bony healing was evident 6 months later; however, joint instability and limited knee flexion were apparent). At final follow-up, the mean International Society of Limb Salvage (ISOLS) graft score was 31 (87%), whereas the mean Musculoskeletal Tumour Society (MSTS) function score was 23 (77%). Conclusions: These preliminary findings indicate that alcohol-inactivated autograft replantation with joint preservation may be effective in treating osteosarcoma of the distal femur in some patients. Larger-scale studies are needed to fully evaluate the efficacy/safety of this approach. © 2014 S. Karger GmbH, Freiburg
- Publication
Oncology Research & Treatment, 2014, Vol 37, Issue 10, p554
- ISSN
2296-5270
- Publication type
Article
- DOI
10.1159/000367799