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- Title
Homocysteine Levels and Oxidative Stress Parameters in Patients With Adult ADHD.
- Authors
Karababa, İbrahim Fatih; Savas, Sermin Nur; Selek, Sehabettin; Cicek, Erdinc; Cicek, Esra Ismet; Asoglu, Mehmet; Bayazit, Huseyin; Kandemir, Hasan; Kati, Mahmut; Ulas, Turgay
- Abstract
<bold>Objective: </bold>In our study, we aimed to evaluate the plasma homocysteine levels and oxidative stress parameters in patients with adult ADHD (A-ADHD).<bold>Method: </bold>Blood samples were taken from 32 A-ADHD patients and 32 controls enrolled in the study and plasma homocysteine, serum folate, vitamin B12, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) were determined. Results were compared between the groups.<bold>Results: </bold>Patients' plasma homocysteine level was significantly lower and serum folate level was significantly higher than the controls. The means of plasma homocysteine and folate levels were statistically significantly different between the groups ( p < .05). However, a statistically significant difference was not detected between groups for mean serum vitamin B12, TAS, TOS, and OSI levels ( p > .05).<bold>Conclusion: </bold>Our study suggests that oxidative balance is not impaired in A-ADHD, and contrary to other psychiatric disorders, homocysteine levels were found to be lower.
- Subjects
VITAMIN B12 metabolism; FOLIC acid metabolism; ANTIOXIDANTS; ATTENTION-deficit hyperactivity disorder; OXIDIZING agents; HOMOCYSTEINE; OXIDATIVE stress; CASE-control method
- Publication
Journal of Attention Disorders, 2017, Vol 21, Issue 6, p487
- ISSN
1087-0547
- Publication type
journal article
- DOI
10.1177/1087054714538657