We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
M. tuberculosis Infection Attributable to Exposure in Social Networks of Tuberculosis Cases in an Urban African Community.
- Authors
Kiwanuka, Noah; Zalwango, Sarah; Kakaire, Robert; Castellanos, Maria Eugenia; Quach, Trang Ho Thu; Whalen, Christopher C
- Abstract
Background The persistence of tuberculosis today and its global disparity send a powerful message that effective tuberculosis control must respond to its regional epidemiology. Active case finding through contact investigation is a standard protocol used for tuberculosis control, but its effectiveness has not been established, especially in endemic areas. Methods To quantify the potential effectiveness of contact investigation in Kampala, Uganda, we used a cross-sectional design to evaluate the social networks of 123 tuberculosis index cases and 124 controls without tuberculosis. Results Tuberculous infection was present in 515 of 989 tuberculosis case contacts (52.1%) and 396 of 1026 control contacts (38.6%; adjusted prevalence ratio, 1.4; 95% CI, 1.3–1.6). The proportion of infected participants with known exposure within the social network of the tuberculosis case was 35%. The population-attributable fraction was 11.1% for any known exposure, with 7.3% attributable to household exposure and 3.4% attributable to extrahousehold exposure. Conclusions This low population-attributable fraction indicates that contact tracing in the social networks of index cases will have only a modest effect in reducing tuberculous infection in a community. New approaches to community-level active case finding are needed.
- Subjects
KAMPALA (Uganda); LATENT tuberculosis; SOCIAL networks; TUBERCULOSIS; AFRICANS; TUBERCULOUS meningitis; CONTACT tracing
- Publication
Open Forum Infectious Diseases, 2024, Vol 11, Issue 5, p1
- ISSN
2328-8957
- Publication type
Article
- DOI
10.1093/ofid/ofae200