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- Title
Influenza virus specific CD8(+) T cells exacerbate infection following high dose influenza challenge of aged mice.
- Authors
Parzych, E M; Dimenna, L J; Latimer, B P; Small, J C; Kannan, S; Manson, B; Lasaro, M O; Wherry, E J; Ertl, H C
- Abstract
Influenza viruses cause severe illnesses and death, mainly in the aged population. Protection afforded by licensed vaccines through subtype-specific neutralizing antibodies is incomplete, especially when the vaccine antigens fail to closely match those of the circulating viral strains. Efforts are underway to generate a so-called universal influenza vaccine expressing conserved viral sequences that induce broad protection to multiple strains of influenza virus through the induction of CD8¿ T cells. Here we assess the effect of a potent antiviral CD8¿ T cell response on influenza virus infection of young and aged mice. Our results show that CD8¿ T cell-inducing vaccines can provide some protection to young mice, but they exacerbate influenza virus-associated disease in aged mice, causing extensive lung pathology and death.
- Publication
BioMed Research International, 2013, Vol 2013, p876314
- ISSN
2314-6133
- Publication type
Journal Article
- DOI
2013/876314