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- Title
Fat-free mass index predicts survival in patients with idiopathic pulmonary fibrosis.
- Authors
Nishiyama, Osamu; Yamazaki, Ryo; Sano, Hiroyuki; Iwanaga, Takashi; Higashimoto, Yuji; Kume, Hiroaki; Tohda, Yuji
- Abstract
ABSTRACT Background and objective Detailed body composition, such as fat-free mass, has not been examined in idiopathic pulmonary fibrosis ( IPF). We investigated whether the fat-free mass index ( FFMI), an index of lean body mass, predicted survival. Methods Forty-four patients with IPF were enrolled in the study. Their body composition was assessed using direct segmental multi-frequency bioelectrical impedance analysis. The degree of correlation between variables of body composition and other variables such as forced vital capacity ( FVC) and survival was examined. Results There was a significant positive correlation between FFMI and FVC, diffusion capacity of the lung for carbon monoxide ( DLCO ) and 6-min walk distance, and a significant negative correlation with age. However, there was no significant correlation between FFMI and percentage predicted FVC or DLCO , with the degree of correlation being similar to that observed for BMI. The mean observation period in the survival analysis was 837.5 ± 407.5 days. A univariate Cox proportional hazard model showed that several variables, but not BMI, were associated significantly with survival. FFMI (hazard ratio ( HR): 0.64, 95% CI: 0.43-0.94, P = 0.02) and percentage predicted FVC ( HR: 0.96, 95% CI: 0.93-0.99, P=0.008) were significant factors in a multivariate model. Conclusion We conclude that FFMI is a significant independent predictor of survival in patients with IPF.
- Subjects
IDIOPATHIC pulmonary fibrosis; LEAN body mass; HUMAN body composition; VITAL capacity (Respiration); BIOELECTRIC impedance; PROPORTIONAL hazards models; PROGNOSIS
- Publication
Respirology, 2017, Vol 22, Issue 3, p480
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.12941