We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A case of "genetically defined" radiation‐induced glioma: 29 years after surgery and radiation for pilocytic astrocytoma.
- Authors
Masui, Kenta; Nitta, Masayuki; Muragaki, Yoshihiro; Kawamata, Takakazu; Satomi, Kaishi; Matsushita, Yuko; Yoshida, Akihiko; Ichimura, Koichi; Tsuda, Masumi; Tanaka, Shinya; Komori, Takashi
- Abstract
Radiation-induced gliomas (RIGs), which occur in a previously irradiated region of the original tumor, represent a rare but well-characterized clinical entity. Integrated diagnosis of the tumor was made as diffuse pediatric-type high-grade glioma, H3-wild type, and IDH-wild type,[[8]] corresponding to RIG. RIGs were traditionally noted to consist of a heterogeneous population and could be diagnosed by exclusion of other tumors.[1] Recent reports demonstrated that RIGs harbor unique molecular features, including a homologous epigenetic profile with sporadic GBM RTK1 tumors.[[2]] Methylation profiling would thus be recommended for the diagnosis of "molecularly defined" RIGs.
- Subjects
ASTROCYTOMAS; GLIOMAS; CENTRAL nervous system tumors; PLATELET-derived growth factor receptors; GENE amplification
- Publication
Neuropathology, 2023, Vol 43, Issue 5, p425
- ISSN
0919-6544
- Publication type
Article
- DOI
10.1111/neup.12903