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- Title
Small Diameter Vascular Prosthesis with a Nonthrombogenic Phospholipid Polymer Surface: Preliminary Study of a New Concept for Functioning in the Absence of Pseudo- or Neointima Formation.
- Authors
Yoneyama, Toshikazu; Ito, Masashi; Sugihara, Ken-ichi; Ishihara, Kazuhiko; Nakabayashi, Nobuo
- Abstract
The purpose of this study was to prepare a small diameter vascular prosthesis functioning without pseudointima formation. A nonthrombogenic phospholipid polymer, the 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer, has a cell membrane-like structure and has demonstrated strong nonthrombogenicity. We have recently prepared 2 kinds of vascular prostheses, 2 mm in diameter, composed of the MPC polymer and segmented polyurethane (SPU). One includes 7.5 wt% MPC polymer (SPU/MPC[7.5] prosthesis), and the other includes 10.0 wt% (SPU/MPC[10] prosthesis). These prostheses were placed in rabbit carotid arteries and were retrieved at 1 and 4 weeks after implantation. A pseudointima was observed at 4 weeks on the SPU/MPC(7.5). For the SPU/MPC(10), the surface was macroscopically clear without a pseudointima even after a 4 week implantation. It appears that the SPU/MPC(10) prosthesis, functioning without a pseudointima, possesses a stronger nonthrombogenicity and would be more applicable for clinical use.
- Subjects
BLOOD vessel prosthesis; PHOSPHOLIPIDS; POLYURETHANES in medicine
- Publication
Artificial Organs, 2000, Vol 24, Issue 1, p23
- ISSN
0160-564X
- Publication type
Article
- DOI
10.1046/j.1525-1594.2000.06433.x