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- Title
Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration.
- Authors
Couch BA; DeMarco GJ; Gourley SL; Koleske AJ; Couch, Brian A; DeMarco, George J; Gourley, Shannon L; Koleske, Anthony J
- Abstract
Amyloid-beta (Abeta) overproduction and dendrite arbor atrophy are hallmarks of Alzheimer's disease. The RhoA GTPase (Rho) signals through Rho kinase (ROCK) to control cytoskeletal dynamics and regulate neuron structure. Hyperactive Rho signaling destabilizes neurons leading to dendritic regression that can be rescued by genetic or pharmacological reduction of ROCK signaling. To understand what effect reduced ROCK signaling has on the dendrite arbors of mice that overproduce Abeta, we administered the ROCK inhibitor fasudil to AbetaPP/PS1 transgenic mice. We report that increased dendrite branching occurs in AbetaPP/PS1 mice and that fasudil promotes lengthening of the dendrite arbors of CA1 pyramidal neurons.
- Publication
Journal of Alzheimer's Disease, 2010, Vol 20, Issue 4, p1003
- ISSN
1387-2877
- Publication type
journal article
- DOI
10.3233/JAD-2010-091114