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- Title
Cancer Therapy Using Ultrahigh Hydrophobic Drug-Loaded Graphene Derivatives.
- Authors
Surajit Some; A-Ryeong Gwon; Eunhee Hwang; Ga-hee Bahn; Yeoheung Yoon; Youngmin Kim; Seol-Hee Kim; Sora Bak; Junghee Yang; Dong-Gyu Jo; Hyoyoung Lee
- Abstract
This study aimed to demonstrate that curcumin (Cur)-containing graphene composites have high anticancer activity. Specifically, graphene-derivatives were used as nanovectors for the delivery of the hydrophobic anticancer drug Cur based on pH dependence. Different Cur-graphene composites were prepared based on polar interactions between Cur and the number of oxygen-containing functional groups of respective starting materials. The degree of drug-loading was found to be increased by increasing the number of oxygen-containing functional groups in graphene-derivatives. We demonstrated a synergistic effect of Cur-graphene composites on cancer cell death (HCT 116) both in vitro and in vivo. As-prepared graphene quantum dot (GQD)-Cur composites contained the highest amount of Cur nano-particles and exhibited the best anticancer activity compared to the other composites including Cur alone at the same dose. This is the first example of synergistic chemotherapy using GQD-Cur composites simultaneous with superficial bioprobes for tumor imaging.
- Subjects
GRAPHENE; QUANTUM dots; POLAR interactions; CANCER treatment; IONIC interactions; ANTINEOPLASTIC agents; CELL death
- Publication
Scientific Reports, 2014, p1
- ISSN
2045-2322
- Publication type
Article
- DOI
10.1038/srep06314