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- Title
Apolipoprotein A-IV: A Multifunctional Protein Involved in Protection against Atherosclerosis and Diabetes.
- Authors
Qu, Jie; Ko, Chih-Wei; Tso, Patrick; Bhargava, Aditi
- Abstract
Apolipoprotein A-IV (apoA-IV) is a lipid-binding protein, which is primarily synthesized in the small intestine, packaged into chylomicrons, and secreted into intestinal lymph during fat absorption. In the circulation, apoA-IV is present on chylomicron remnants, high-density lipoproteins, and also in lipid-free form. ApoA-IV is involved in a myriad of physiological processes such as lipid absorption and metabolism, anti-atherosclerosis, platelet aggregation and thrombosis, glucose homeostasis, and food intake. ApoA-IV deficiency is associated with atherosclerosis and diabetes, which renders it as a potential therapeutic target for treatment of these diseases. While much has been learned about the physiological functions of apoA-IV using rodent models, the action of apoA-IV at the cellular and molecular levels is less understood, let alone apoA-IV-interacting partners. In this review, we will summarize the findings on the molecular function of apoA-IV and apoA-IV-interacting proteins. The information will shed light on the discovery of apoA-IV receptors and the understanding of the molecular mechanism underlying its mode of action.
- Subjects
CHYLOMICRONS; THROMBOTIC thrombocytopenic purpura; BLOOD platelet aggregation; ATHEROSCLEROSIS; LIPID metabolism; PROTEINS
- Publication
Cells (2073-4409), 2019, Vol 8, Issue 4, p319
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells8040319