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- Title
Iridium- and Palladium-Based Catalysts in the Pharmaceutical Industry.
- Authors
López, Óscar; Padrón, José M.
- Abstract
Transition metal catalysts play a vital role in a wide range of industrial organic processes. The large-scale production of chemicals relying on catalyzed organic reactions represents a sustainable approach to supply society with end products for many daily life applications. Homogeneous (mainly for academic uses) and heterogeneous (crucial in industrial processes) metal-based catalysts have been developed for a plethora of organic reactions. The search for more sustainable strategies has led to the development of a countless number of metal-supported catalysts, nanosystems, and electrochemical and photochemical catalysts. In this work, although a vast number of transition metals can be used in this context, special attention is devoted to Ir- and Pd-based catalysts in the industrial manufacture of pharmaceutical drugs. Pd is by far the most widely used and versatile catalyst not only in academia but also in industry. Moreover, Ir-based complexes have emerged as attractive catalysts, particularly in asymmetric hydrogenation reactions. Ir- and Pd-based asymmetric reductions, aminations, cross-coupling reactions, and C–H activation are covered herein in the production of biologically active compounds or precursors; adaptation to bulk conditions is particularly highlighted.
- Subjects
TRANSITION metal catalysts; IRIDIUM catalysts; BIOACTIVE compounds; CATALYSTS; ALLYLIC amination; PHARMACEUTICAL industry; TRANSITION metals
- Publication
Catalysts (2073-4344), 2022, Vol 12, Issue 2, p164
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal12020164