We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Simplified Method to Optimize Enzymatic Esters Syntheses in Solvent-Free Systems: Validation Using Literature and Experimental Data.
- Authors
Sousa, Ronaldo Rodrigues de; Silva, Ayla Sant'Ana da; Fernandez-Lafuente, Roberto; Ferreira-Leitão, Viridiana Santana
- Abstract
The adoption of biocatalysis in solvent-free systems is an alternative to establish a greener esters production. An interesting correlation between the acid:alcohol molar ratio and biocatalyst (immobilized lipase) loading in the optimization of ester syntheses in solvent-free systems had been observed and explored. A simple mathematical tool named Substrate-Enzyme Relation (SER) has been developed, indicating a range of reaction conditions that resulted in high conversions. Here, SER utility has been validated using data from the literature and experimental assays, totalizing 39 different examples of solvent-free enzymatic esterifications. We found a good correlation between the SER trends and reaction conditions that promoted high conversions on the syntheses of short, mid, or long-chain esters. Moreover, the predictions obtained with SER are coherent with thermodynamic and kinetics aspects of enzymatic esterification in solvent-free systems. SER is an easy-to-handle tool to predict the reaction behavior, allowing obtaining optimum reaction conditions with a reduced number of experiments, including the adoption of reduced biocatalysts loadings.
- Subjects
LIPASES; ENZYMES; BIOCATALYSIS; ESTERIFICATION; ESTERS
- Publication
Catalysts (2073-4344), 2021, Vol 11, Issue 11, p1357
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal11111357