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- Title
Ring-Opening of Epoxides with Amines for Synthesis of β-Amino Alcohols in a Continuous-Flow Biocatalysis System.
- Authors
Du, Li-Hua; Xue, Miao; Yang, Meng-Jie; Pan, Yue; Zheng, Ling-Yan; Ou, Zhi-Min; Luo, Xi-Ping
- Abstract
An efficient method for the preparation of β-amino alcohols catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow reactor was developed. The eco-friendly biocatalyst combined with continuous-flow reaction technology displayed high efficiency in the synthesis of β-amino alcohols. The benign reaction conditions (35 °C) and short residence time (20 min), together with the use of low cost and readily available starting materials, make this synthetic approach a promising alternative to current β-amino alcohol synthesis.
- Subjects
EPOXY compounds; BIOCATALYSIS; CONTINUOUS flow reactors; AMINES; ALCOHOL
- Publication
Catalysts (2073-4344), 2020, Vol 10, Issue 12, p1419
- ISSN
2073-4344
- Publication type
Article
- DOI
10.3390/catal10121419