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- Title
FC-20 Efficacy of griseofulvin for juvenile cellulitis in dogs.
- Authors
Shibata, K.; Nagata, M.
- Abstract
Juvenile cellulitis is an uncommon idiopathic granulomatous and pustular disorder with submandibular lymph node involvement that usually occurs in puppies. Currently, large doses of glucocorticoids are the treatment of choice. Griseofulvin is a fungistatic antibiotic that also has immunomodulatory properties and is occasionally used in human patients with idiopathic inflammatory skin disorders. The purpose of this study was to investigate the efficacy of griseofulvin in the treatment of juvenile cellulitis in dogs. Six dogs with juvenile cellulitis were investigated. The diagnosis was based on both clinical features and standard diagnostic procedures, and fungal disorders were carefully ruled out. These dogs were treated with griseofulvin (14.2–34 mg/kg orally, twice daily) without any other treatment. On the basis of clinical observation, the efficacy of griseofulvin was evaluated as excellent (complete resolution within 2 weeks), good (complete resolution within 4 weeks), fair (>4 weeks for complete resolution), and poor (unresolved). Two cases were evaluated as excellent, and four cases were good. All cases were completely resolved within 3 weeks. No adverse reactions were recognized in any of the dogs. In this study, griseofulvin appeared to be effective in the treatment of canine juvenile cellulitis. Although the aetiology remains uncertain, it is postulated that griseofulvin could induce down-regulatory signals within the lesions. Further investigation is needed to understand the clinical effects of griseofulvin. Funding: Self-funded.
- Subjects
CELLULITIS; ETIOLOGY of diseases; DOGS; DISEASES; DIAGNOSIS; THERAPEUTICS; PRECANCEROUS conditions
- Publication
Veterinary Dermatology, 2004, Vol 15, p26
- ISSN
0959-4493
- Publication type
Abstract
- DOI
10.1111/j.1365-3164.2004.411_20.x