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- Title
Increased maternal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) associated with older age at diagnosis of Type 1 diabetes in offspring N. J. Leech et al. Phenotype and diagnosis of Type 1 diabetes.
- Authors
Leech, N. J.; O'Sullivan, J.; Avery, P.; Howey, C.; Burling, K.; Iyer, S.; Pascoe, L.; Walker, M.; Cheetham, T.
- Abstract
Aims Obesity and insulin resistance have been linked to rising incidence and earlier onset of Type 1 diabetes. Inherited differences in insulin action might also influence the evolution of Type 1 diabetes.Our aim was to determine whether parental BMI and insulin resistance influences age of onset of Type 1 diabetes in their offspring. Methods BMI standard deviation score and age at diagnosis of Type 1 diabetes was examined in 227 children, and in 206 of these was compared with local matched control subjects. Non-diabetic parents of a subgroup of 80 children with Type 1 diabetes were recruited. ParentalBMIwas compared with local adult control subjects. The relationship between parental BMI, waist-hip ratio, homeostasis model assessment of insulin resistance (HOMA-IR), leptin and adiponectin levels and age at diagnosis of Type 1 diabetes in offspring was examined. Results We found no relationship between age at diagnosis of Type 1 diabetes in children and BMI standard deviation score (P = 0.5). Children with Type 1 diabetes and their parents were heavier than matched control subjects (mean BMI standard deviation score ± sd in children = 0.66 ± 1.06 vs. 0.32 ± 1.16 in control subjects, P = 0.002; mean parental BMI ± sd 27.7 ± 0.4 vs. 25.5 ± 0.4 kg /m2 in control subjects; P < 0.0001). Maternal HOMA-IR accounted for 20% of variation in age at diagnosis (P < 0.001) with increasing maternal insulin resistance associated with later age at diagnosis of Type 1 diabetes. Conclusions Childrenwith Type 1 diabetes and their parents have an increased BMI at diagnosis.Maternal insulin resistance is associated with later onset of Type 1 diabetes in children.
- Subjects
DIAGNOSIS of diabetes; DIABETES risk factors; AGE distribution; ANALYSIS of variance; COMPUTER software; ENZYME-linked immunosorbent assay; INSULIN; INSULIN resistance; MOTHERS; PEPTIDE hormones; REGRESSION analysis; STATISTICS; U-statistics; LEPTIN; DATA analysis; BODY mass index; WAIST-hip ratio; BLOOD; DISEASE complications; PREGNANCY
- Publication
Diabetic Medicine, 2010, Vol 27, Issue 12, p1450
- ISSN
0742-3071
- Publication type
Article
- DOI
10.1111/j.1464-5491.2010.03130.x